Orb of Alchemy in Path of Exile 2 is a highly useful item that upgrades the quality of an item to a rare (gold-tier) status. This orb allows players to transform a basic item into a higher-quality rare item with better attributes. The use of the Orb of Alchemy is typically employed when players want to convert a simple item into a rare one with improved stats that can be more beneficial in advanced gameplay and tougher combat scenarios. This orb is especially useful for players looking to upgrade their gear and acquire higher levels of power and effectiveness.

The orb is also traded in the game’s market and can have a significant impact on the improvement and enhancement of a player's equipment. The Orb of Alchemy, when combined with other orbs, serves as one of the key tools for progressing in the game, allowing players to acquire new, optimized attributes for their gear. This orb is particularly valuable during the mid and late stages of the game for improving equipment and crafting rare items with unique properties.